Prescription Medications And Night Sweats


Did you know that nearly 1 in 3 people on prescription medications experience night sweats as a side effect? Night sweats, or excessive sweating during sleep, can be a distressing and disruptive issue, impacting your well-being and leaving you in search of answers. Interestingly, one of the common causes of night sweats is the usage of certain prescription medications.

In this article, we will explore the connection between prescription medications and night sweats, breaking down complex medical information into easily understandable facts.

🛌⚠️ Men: Night sweats can have many causes. Read out complete overview of the topic on the Causes of Night Sweats in Men: Triggers, Remedies, and FAQs

🛌⚠️ Women: Night sweats can have many causes. Read out complete overview of the topic on the Causes of Night Sweats in Women: Triggers, Remedies, and FAQs

I. Background Information

A. Definition

Night sweats, also known as sleep hyperhidrosis, are episodes of excessive sweating experienced during sleep, usually unrelated to a hot environment. These episodes can be disruptive to an individual’s rest, often leading to wet bedding and clothing, and impacting their overall quality of life.

B. Prevalence

Night sweats are more common in women and older adults, but can affect anyone. In fact, research indicates that around 3% to 41% of the general adult population experiences night sweats. The wide range in prevalence is attributed to variations in the definition and measurement of night sweats, but it is clear that this issue affects a significant portion of individuals.

C. Causes and Risk Factors

Prescription medications are one possible cause of night sweats[1], although there are several other factors that can contribute to this condition, such as:

D. Medications That Can Make You Sweat At Night

Here is a list of some medications that can potentially cause night sweats:

  1. Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) like Prozac or Zoloft, serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs).
  2. Antipsychotics: Medications used to treat schizophrenia, bipolar disorder, or other severe mental health conditions.
  3. Hormone replacement therapy: Estrogen and progesterone therapies for menopause symptoms, and testosterone replacement therapy for men with low testosterone levels.
  4. Diabetes medications: Insulin and sulfonylureas, which help regulate blood sugar levels.
  5. Pain relievers: Opioids, such as codeine, morphine, and oxycodone, may cause night sweats in some individuals.
  6. Antipyretics: Medications like acetaminophen (Tylenol) or nonsteroidal anti-inflammatory drugs (NSAIDs) taken in high doses or for extended periods can cause night sweats.
  7. Steroids: Corticosteroids like prednisone, which are used to treat inflammation and autoimmune disorders, may lead to night sweats.

Keep in mind that individual reactions to medications may vary, and this list is not exhaustive. If you experience night sweats while taking any medication, consult your healthcare provider for guidance.

Identifying the specific cause of night sweats is crucial for developing appropriate treatment plans and managing the condition effectively.

II. Symptoms and Diagnosis

A. Common Symptoms

When it comes to night sweats caused by prescription medications, the primary symptom is excessive sweating during sleep. This excessive sweating can lead to wet bedding and clothing, causing sleep disturbances and discomfort. However, it’s important to remember that other symptoms may also be present, depending on the specific medication and individual reaction. These could include:

  • Headaches
  • Dizziness
  • Upset stomach
  • Mood changes

B. Diagnostic Criteria

Diagnosing night sweats due to prescription medications requires a detailed examination and assessment by a healthcare professional. The diagnosis process may involve the following steps:

  1. Patient history: A thorough discussion of the patient’s symptoms, current medications, and health history helps the healthcare provider identify possible connections between the night sweats and prescription drug use.
  2. Physical examination: The doctor performs a comprehensive physical examination to evaluate the patient’s overall health and rule out other conditions that may be causing the night sweats.
  3. Medication review: The healthcare provider assesses the types of prescription medications the patient is taking, considering any known side effects and potential interactions that might contribute to the night sweats.

If you are experiencing persistent or severe night sweats and suspect a connection to your prescription medications, it is essential to consult with a healthcare professional for a proper assessment and personalized recommendations.

III. Treatment and Management

Effectively addressing night sweats caused by prescription medications requires a comprehensive approach that consists of conventional treatments, alternative options, and lifestyle changes. Developing a suitable management plan can help alleviate symptoms and improve overall well-being.

A. Conventional Treatments

Your healthcare provider may recommend or prescribe the following treatments if you’re experiencing night sweats due to prescription medications:

  1. Medication adjustments or alternatives: In some cases, your healthcare provider may adjust the dosage or prescribe an alternative medication with fewer side effects, including night sweats. However, it’s crucial to consult a healthcare professional to weigh the benefits and potential risks of any changes.

B. Alternative Treatments

Some individuals explore alternative treatments to manage night sweats related to prescription medications:

  1. Herbal supplements: Natural remedies, such as black cohosh, evening primrose oil, and sage, have been used to alleviate night sweats. However, it’s essential to consult a healthcare professional before trying any herbal supplement or treatment.
  2. Acupuncture: This traditional Chinese medicine practice involving the insertion of fine needles at specific pressure points has been known to alleviate night sweats for some individuals. Consult a certified acupuncturist to explore this option.

C. Lifestyle Changes

Incorporating specific lifestyle modifications can help manage prescription medication-related night sweats:

  1. Sleep environment modifications: Invest in cooling mattress pads or pillows, moisture-wicking sheets, and breathable sleepwear to help regulate your body temperature during sleep and minimize night sweats.
  2. Bedtime routine: Establish a regular bedtime routine that includes relaxing activities, such as reading or taking a warm bath, to signal your body that it’s time to sleep. Avoid stimulants like caffeine, nicotine, and electronic screens close to bedtime.

IV. Complications and Long-term Effects

A. Possible Complications

Night sweats caused by prescription medications, if not addressed, can result in various complications, such as:

  • Sleep deprivation
  • Reduced quality of life
  • Weakened immunity
  • Mood disorders

Persistent night sweats disrupt sleep quality, potentially leading to chronic sleep deprivation and associated issues, such as increased stress, irritability, and difficulty concentrating.

B. Long-term Effects

If medication-related night sweats persist without intervention, they can have a significant impact on an individual’s long-term physical and emotional well-being. Some of the potential long-term effects include:

  • Increased stress and anxiety
  • Depression due to chronic sleep disruption
  • Memory impairment and cognitive decline
  • Reduced work performance and a higher risk of accidents
  • Worsened overall quality of life

Given these potential consequences, it is crucial to address prescription medication-related night sweats and work with a healthcare provider to develop effective management and treatment strategies.

V. Prevention and Coping Strategies

A. Prevention Tips

To minimize the occurrence of night sweats related to prescription medications, consider the following prevention tips:

  • Discuss potential side effects: Talk to your healthcare provider about the possible side effects of new medications, including night sweats, before starting the treatment.
  • Stay informed: Research and stay up-to-date on potential triggers and side effects associated with your medications to better manage your symptoms.
  • Address underlying health conditions: Seek treatment for any health issues that could contribute to night sweats or make symptoms worse.
  • Regular medical check-ups: Regularly consult with your healthcare provider to monitor the effectiveness and side effects of your medications.

B. Coping Strategies

The following coping strategies can help you better manage the challenges associated with medication-related night sweats:

  • Seek emotional support: Connect with friends, family, or online support groups to discuss your experiences and learn from others facing similar challenges.
  • Implement stress reduction techniques: Incorporate relaxation practices such as meditation, deep breathing, or yoga into your daily routine to alleviate stress and ease night sweats symptoms.
  • Optimize sleep environment: Use cooling mattress pads, breathable bedding, and maintain a comfortable room temperature to improve sleep quality and reduce night sweat episodes.
  • Establish a bedtime routine: Developing a consistent sleep schedule and engaging in relaxing activities before bed can help signal your body that it is time to sleep and ease night sweat symptoms.

VI. Frequently Asked Questions

How to stop sweating caused by medication?

To stop sweating caused by medication, consider discussing the issue with your healthcare provider. They may adjust the dosage, change the medication, or recommend alternative treatments. Additionally, staying hydrated, wearing moisture-wicking clothes, using fans or air conditioning, and applying antiperspirant can help manage excessive sweating.

What drugs cause you to sweat profusely

Some medications that may cause excessive sweating include antidepressants, antipsychotics, hormone replacement therapy, diabetes medications, pain relievers, and certain antipyretics. Individual reactions to medications may vary, so it’s crucial to consult a healthcare professional for personalized advice.

How to stop night sweats caused by antidepressants

To stop night sweats caused by antidepressants, discuss your symptoms with your healthcare provider. They may adjust the dosage, change the medication, or suggest alternative treatments. Additionally, maintain a cool sleeping environment, use moisture-wicking beddings, and avoid caffeine and alcohol before bedtime to help alleviate night sweats.

Can taking Tylenol cause night sweats?

Tylenol (acetaminophen) can sometimes cause night sweats as a side effect, particularly when taken in high doses or for an extended period. If you experience night sweats while taking Tylenol, consult your healthcare provider for guidance.

Do NSAIDs cause night sweats?

Nonsteroidal anti-inflammatory drugs (NSAIDs) can occasionally cause night sweats as a side effect. However, individual reactions to NSAIDs may vary. If you experience night sweats while taking NSAIDs, consult your healthcare provider for guidance.


In conclusion, it is essential to be aware that prescription medications can be a cause of night sweats, impacting one’s overall well-being. If you experience medication-related night sweats, consulting with your healthcare provider is crucial in diagnosing and effectively managing the condition.

Medical Disclaimer: This article is for informational purposes only and should not be considered professional medical advice. It is always recommended to consult with a healthcare professional before making any changes to your treatment plan, diet, or lifestyle. is not responsible for any actions taken as a result of the information provided in this article.


  1. Cheshire WP, Fealey RD. Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. Drug Saf. 2008;31(2):109-26. doi: 10.2165/00002018-200831020-00002. PMID: 18217788.